ea0029p1760 | Thyroid cancer | ICEECE2012
Balla B
, Kosa J
, Tobias B
, Halaszlaki C
, Takacs I
, Horvath H
, Speer G
, Horanyi J
, Nagy Z
, Jaray B
, Szekely E
, Lakatos P
Background: It is well established that 1,25-dihydroxyvitamin D3 (1,25-D3) inhibits cell growth and induces apoptosis in numerous tumors. Increased expression of 1,25-D3 inactivating enzyme, (24-hydroxylase - CYP24A1), has been observed in numerous thyroid cancer cell lines after calcitriol treatment in vitro. We examined the expression of CYP24A1 as well as the activating 1-α-hydroxylase (CYP27B1) gene in human thyroid cancer tissue.Methods:...